Cardiac effects of cocaine: a review.

摘要: Over the past 15 years, there has been a dramatic increase in abuse of purified cocaine preparations throughout industrialized world. The potential lethality drug is now recognized, and growing series case reports indicate that cardiotoxicity may be an important factor morbidity mortality associated with drug. Acute myocardial infarction demonstrated risk both subjects without pre-existent coronary artery disease. arrhythmogenic less clear appears to have overemphasized, although several documented cases ventricular arrhythmia following use reported. Cardiomyopathy myocarditis also described, but etiologic relationship presently inferential. Based upon presumed pathophysiologic mechanisms, beta adrenergic blocking agents are recommended for arrhythmias, calcium channel and/or nitrates ischemic syndromes related cocaine. It emphasized these recommendations based paucity relevant clinical studies, controlled trials establish their efficacy not performed.