High dose intravenous methylprednisolone resolves esophageal stricture resistant to balloon dilatation with intralesional injection of dexamethasone

摘要: One of the most serious problems in patients with long-gap esophageal atresia or corrosive esophagitis is stricture, which may require resection and replacement. We describe two cases persistent stricture successfully managed by high dose intravenous methylprednisolone following balloon dilatation. High-dose gradual tapering (daily 25, 15, 10, 5, 2 mg/kg for 4 days each) plus cimetidine ampicillin 1 week was intravenously administrated immediately after dilatation stenosis. This followed oral prednisolone 2, 1, 0.5 stricture. High therapy given to patients. patient a 5-year-old boy who had undergone repair esophagus resulting severe anastomotic stenosis 3 cm length. The other case 10-year-old caused alkali ingestion. Both been requiring intralesional injection dexamethasone every weeks more than year tolerate feeding. After high-dose protocol initiated, symptoms dysphagia choking dramatically improved both patients, they remained symptom-free 8 7 months. There were complications moon faces that resolved concomitantly withdrawal cases. addition dilation an effective therapeutic strategy strictures.