Synthesis and cytotoxicity of brefeldin A conjugated monomethoxy-poly(ethylene glycol)-b-poly(L-lactide) polymeric micelles.
作者： Wanyun Liu , Junchao Wei , Ping Huo , Yunhua Lu , Yiwang Chen
DOI: 10.1080/09205063.2012.729489
关键词:
摘要: A diblock copolymer of monomethoxy-poly(ethylene glycol)-b-poly(L-lactide) (MePEG-PLLA)/brefeldin (BFA) conjugate was synthesized by the reaction carboxyl-terminated MePEG-PLLA with BFA in presence dicyclohexylcarbodiimide and dimethylaminopyridine. The conjugation efficiency found to be 95%. Its structure confirmed 1H nuclear magnetic resonance gel permeation chromatography. MePEG-PLLA/BFA could self-assemble into micelles aqueous solutions a low critical micelle concentration 1.8 × 10−3 g/L. Dynamic light scattering transmission electron microscopy analyses revealed their spherical an average diameter 120 nm. release profiles PBS were measured high performance liquid chromatography (HPLC), demonstrating that controlled can gained for long time. vitro antitumor activity against human liver carcinoma HepG2 cells evalu...
sci-hub.se 参考文章(22)
AKIRA TAKATSUKI, ISAMU YAMAGUCHI, GAKUZO TAMURA, TOMOMASA MISATO, KEI ARIMA, CORRELATION BETWEEN THE ANTI-ANIMAL AND ANTI-PLANT-VIRUS ACTIVITIES OF SEVERAL ANTIBIOTICS The Journal of Antibiotics. ,vol. 22, pp. 442- 445 ,(1969) , 10.7164/ANTIBIOTICS.22.442
Xiuli Hu, Xiabin Jing, Yonghui Zheng, Shi Liu, Yanhui Wan, Xiangfu Song, Ti Tong, Anti-tumor activity of biodegradable polymer-paclitaxel conjugate micelles on Lewis lung cancer mice models. Journal of Biomaterials Science-polymer Edition. ,vol. 22, pp. 1131- 1146 ,(2012) , 10.1163/092050610X500570
Ankush B. Argade, Rajesh Devraj, Jeffrey A. Vroman, Rudiger D. Haugwitz, Melinda Hollingshead, Mark Cushman, Design and Synthesis of Brefeldin A Sulfide Derivatives as Prodrug Candidates with Enhanced Aqueous Solubilities Journal of Medicinal Chemistry. ,vol. 41, pp. 3337- 3346 ,(1998) , 10.1021/JM970746G
Xuefei Zhang, Yuxin Li, Xuesi Chen, Xiuhong Wang, Xiaoyi Xu, Qizhi Liang, Junli Hu, Xiabin Jing, Synthesis and characterization of the paclitaxel/MPEG-PLA block copolymer conjugate. Biomaterials. ,vol. 26, pp. 2121- 2128 ,(2005) , 10.1016/J.BIOMATERIALS.2004.06.024
Ji-Wen Zhu, Hitoshi Hori, Hisao Nojiri, Takahiko Tsukuda, Zenei Taira, Synthesis and activity of brefeldin a analogs as inducers of cancer cell differentiation and apoptosis Bioorganic & Medicinal Chemistry Letters. ,vol. 7, pp. 139- 144 ,(1997) , 10.1016/S0960-894X(96)00588-4
V. L. SINGLETON, N. BOHONOS, A. J. ULLSTRUP, Decumbin, a new compound from a species of Penicillium. Nature. ,vol. 181, pp. 1072- 1073 ,(1958) , 10.1038/1811072A0
Meredith Hans, Karin Shimoni, Dganit Danino, Steven J. Siegel, Anthony Lowman, Synthesis and characterization of mPEG-PLA prodrug micelles. Biomacromolecules. ,vol. 6, pp. 2708- 2717 ,(2005) , 10.1021/BM050188K
Zhigang Xie, Tiancheng Lu, Xuesi Chen, Changhai Lu, Yonghui Zheng, Xiabin Jing, Triblock poly(lactic acid)‐b‐poly(ethylene glycol)‐b‐poly(lactic acid)/paclitaxel conjugates: Synthesis, micellization, and cytotoxicity Journal of Applied Polymer Science. ,vol. 105, pp. 2271- 2279 ,(2007) , 10.1002/APP.26236
Ji-Wen Zhu, Hideko Nagasawa, Fumi Nagura, Saharuddin B Mohamad, Yoshihiro Uto, Kazuto Ohkura, Hitoshi Hori, Elucidation of strict structural requirements of brefeldin A as an inducer of differentiation and apoptosis. Bioorganic & Medicinal Chemistry. ,vol. 8, pp. 455- 463 ,(2000) , 10.1016/S0968-0896(99)00297-7
Dan Peer, Jeffrey M. Karp, Seungpyo Hong, Omid C. Farokhzad, Rimona Margalit, Robert Langer, Nanocarriers as an emerging platform for cancer therapy Nature Nanotechnology. ,vol. 2, pp. 751- 760 ,(2007) , 10.1038/NNANO.2007.387