Serum marker KL-6/MUC1 for the diagnosis and management of interstitial pneumonitis

摘要: Interstitial pneumonitis includes more than a hundred diseases in which alveolitis is the main manifestation of affected lung. Symptoms such as dry cough and exertional dyspnea, fine crackles on chest auscultation, interstitial infiltrates X-ray films CT scans, respiratory function tests, Ga-67 scintigraphy have been used for diagnosis evaluation disease activity. However, poor prognosis some types has not improved. We discovered high molecular weight mucin-like antigen, designated KL-6, also known MUC1. The serum level KL-6/MUC1 was elevated 70-100% patients with pneumonitis, pulmonary fibrosis (either idiopathic or related to collagen-vascular disorders), hypersensitivity sarcoidosis, radiation pneumonitis. levels were significantly higher active those inactive disease. In contrast, noninterstitial lung did show significant elevation KL-6/MUC1. Furthermore, found be an early predictive marker therapeutic effect high-dose corticosteroids rapidly progressing fibrosis. These results indicate that may useful monitoring