KL-6 mucin expression in carcinoma of the ampulla of Vater: Association with cancer progression

作者: Wei Tang

DOI: 10.3748/WJG.V11.I35.5450

关键词:

摘要: AIM: To assess histochemical expression of KL-6 and its clinicopathological significance in carcinoma the ampulla Vater. METHODS: Ampullary tissues were collected from 38 patients who underwent pancreatoduodenectomy or local resection. Tissues subjected to immunohi-stochemical analysis using antibody. RESULTS: Positive staining ampullary cells was observed 26 (68.4%) cases. Staining not found surrounding non-cancer regions tissues. Remarkable invasive pancreatic duodenal metastatic lymph nodes. related node metastasis (P = 0.020), invasion 0.016), 0.034), advanced stage TNM clinical classification 0.010). Survival showed that positive a poorer prognosis 0.029). CONCLUSION: The aberrant mucin is significantly unfavorable behaviors Vater.

参考文章(30)
Xiao Wei Li, Studies on mechanism of Sialy Lewis-X antigen in liver metastases of human colorectal carcinoma World Journal of Gastroenterology. ,vol. 7, pp. 425- 430 ,(2001) , 10.3748/WJG.V7.I3.425
Sasaki A, Kitano S, Matsumoto T, Yoshida T, Morii Y, Yokoyama H, Shibata K, Patterns of lymph node metastasis in carcinoma of the ampulla of Vater. Hepato-gastroenterology. ,vol. 47, pp. 880- 883 ,(2000)
A Nakao, A Harada, W Kishimoto, S Takeda, H Takagi, T Nonami, K Ito, Prognosis of cancer of the duodenal papilla of Vater in relation to clinicopathological tumor extension. Hepato-gastroenterology. ,vol. 41, pp. 73- 78 ,(1994)
Norihiko Kokudo, Mayumi Usuda, Masami Minagawa, Masatoshi Makuuchi, Yasuji Seyama, Naoya Kojima, Qian Guo, Wei Tang, Munehiro Nakata, Yasuhiko Sugawara, Histochemical expression of sialoglycoconjugates in carcinoma of the papilla of Vater. Hepato-gastroenterology. ,vol. 52, pp. 67- 71 ,(2005)
Shoji Nakamori, David M. Ota, Karen R. Cleary, Keiro Shirotani, Tatsuro Irimura, MUC1 mucin expression as a marker of progression and metastasis of human colorectal carcinoma Gastroenterology. ,vol. 106, pp. 353- 361 ,(1994) , 10.1016/0016-5085(94)90592-4
Nobuoki Kohno, Serum marker KL-6/MUC1 for the diagnosis and management of interstitial pneumonitis The Journal of Medical Investigation. ,vol. 46, pp. 151- 158 ,(1999)
Sen-itiroh Hakomori, Tumor Malignancy Defined by Aberrant Glycosylation and Sphingo(glyco)lipid Metabolism Cancer Research. ,vol. 56, pp. 5309- 5318 ,(1996)
M Fogel, P Altevogt, V Schirrmacher, Metastatic potential severely altered by changes in tumor cell adhesiveness and cell-surface sialylation. Journal of Experimental Medicine. ,vol. 157, pp. 371- 376 ,(1983) , 10.1084/JEM.157.1.371