Expression of PACE4 in chemically induced carcinomas is associated with spindle cell tumor conversion and increased invasive ability

摘要: Gene expression changes associated with the conversion of squamous cell carcinoma (SCC) to a more advanced malignant spindle (SPCC) were determined by differential display. Using an animal model human SCC progression, we provide evidence increased PACE4 in SPCC lines and primary tumors induced chemical carcinogenesis protocols, thus implicating this proprotein convertase process tumor progression. Exogenous overexpression cDNA mouse cells low invasive ability resulted enhanced invasiveness that was absent parental or mock-transfected cells. In addition, PACE4-transfected acquired prostromelysin 3 into its active enzyme form. Taken together, these results show up-regulation is suggests activation essential substrates, such as metalloproteinase stromelysin 3, required for invasion.