Lead, hypertension, and the renin-angiotensin system in rats.
作者： Stevo Julius , Jeffrey M. Shulak , Arthur J. Vander , Winona Victery , Peter Schoeps
DOI: 10.5555/URI:PII:0022214382902967
关键词:
摘要: Rats were exposed continuously to Pb in utero and after birth by giving their mothers, during pregnancy lactation, drinking water containing 0, 100, or 500 ppm (as acetate) then continuing this regimen weaning. Male rats receiving 100 developed a significant elevation of systolic blood pressure (152 +/- 3.7 mm Hg vs. 135 5.6 for controls) at 3 1/2 months remained hypertensive until sacrifice 6 months; normotensive. Both females At plasma renin activity (PRA) was significantly reduced the male group but normal group. There dose-dependent decreases All/PRA ratio renal renin. Pulmonary converting enzyme not changed exposure. Blood (Pb) 40 71 ..mu..g/dl, respectively, kidney 4.8 22.9 ..mu..g/gm. Renal histology We conclude that doses which produce seen many people are capable including modest hypertension rats; higher fail do so. The is associated with reduction PRA All andmore » therefore unlikely be due hyperactivity renin-angiotensin system (RAS).« less
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