Human artificial chromosome (HAC) for measuring chromosome instability (CIN) and identification of genes required for proper chromosome transmission
作者： Natalay Kouprina , Mikhail Liskovykh , Nikolai Petrov , Vladimir Larionov
DOI: 10.1016/J.YEXCR.2019.111805
关键词:
摘要: Chromosomal instability (CIN) is one of the characteristics cancer inherent for tumor initiation and progression, which defined as a persistent, high rate gain/loss whole chromosomes. In vast majority human tumors molecular basis CIN remains unknown. The development conceptually simple colony color sectoring assay that measures yeast artificial chromosome (YAC) loss provided powerful genetic tool to assess mis-segregation also identified 937 genes involved in this process. Similarly, (HAC)-based has been recently developed applied quantify events cells. This allowed identification novel library protein kinases. Among them are PINK1, TRIO, IRAK1, PNCK, TAOK1. HAC-based may be screen siRNA, shRNA CRISPR-based libraries identify complete spectrum genes. will reveal new insights into mechanisms segregation expedite therapeutic strategies target phenotype
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