Dendritic cells derived from HOXB4-immortalized hematopoietic bone marrow cells
作者： Abdul Mannan Baru , Jayendra Kumar Krishnaswamy , Anchana Rathinasamy , Michaela Scherr , Matthias Eder
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摘要: Dendritic cells (DCs) are essential for the generation and modulation of cell-mediated adaptive immunity against infections. DC-based vaccination involves transplantation ex vivo-generated DCs loaded with antigen in vitro, but remains limited by number autologous or allogeneic cells. While vitro expansion differentiation hematopoietic stem (HSCs) into seems to be most viable alternative overcome this problem, complexity HSC has posed significant limitations clinical application. We immortalized lineage-depleted murine bone marrow (lin−BM) HOXB4, differentiated them CD11c+MHCII+ DCs. These showed typical DC phenotype upregulated surface expression co-stimulatory molecules on stimulation various toll-like receptor ligands. efficiently presented exogenous T-cells via major histocompatibility complex (MHC) I II viral infection. Finally, they ...
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