Advantages of the net benefit regression framework for trial-based economic evaluations of cancer treatments: an example from the Canadian Cancer Trials Group CO.17 trial

摘要: Economic evaluations commonly accompany trials of new treatments or interventions; however, regression methods and their corresponding advantages for the analysis cost-effectiveness data are not widely appreciated. To illustrate regression-based economic evaluation, we review a conducted by Canadian Cancer Trials Group’s Committee on Analysis implement net benefit regression. Net offers simple option analyses person-level data. By placing evaluation in framework, techniques can facilitate provide solutions to encountered challenges (e.g., need adjust potential confounders, identify key patient subgroups, and/or summarize “challenging” findings, like when more effective regimen has be cost-saving). patient-level from clinical trial) use enhance results.