Cytokine profile and proviral load among Japanese immigrants and non-Japanese infected with HTLV-1 in a non-endemic area of Brazil

摘要: The lifetime risk of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) development differs among ethnic groups. To better understand these differences, this prospective cohort study was conducted to investigate the cytokine profile and HTLV-1 proviral load (PVL) in Japanese non-Japanese populations with HAM/TSP asymptomatic carriers (ACs). serum IL-2, IL-4, IL-6, IL-10, IL-17, TNF-α, IFN-γ levels were quantified using Cytometric Bead Array 40 HTLV-1-infected patients (11 29 ACs) 18 healthy controls (HCs) Brazil. Among ACs, 15 descendants 14 non-Japanese. Of 11 HAM/TSP, only one a descendant. PVL by real-time PCR. 2.7-fold higher than ACs. Regardless clinical outcome, significantly younger 60 years older patients. ACs had IL-10 concentrations that HCs. also showed IL-6 those According age, years. positive correlation between IL-17 negative IFN-γ. In all significant observed IL-2 detected TNF-α. Only 6.25% symptomatic carriers, compared 41.67% conclusion, high intrinsicaly associated HAM/TSP. A IL10 found over old, which group depicts background may interfere host immune status. More researches need be undertaken regarding genetic low frequency individuals.