Clinical efficacy of the RIT 4237 live attenuated bovine rotavirus vaccine in infants vaccinated before a rotavirus epidemic.
作者： Timo Vesikari , Erika Isolauri , Andrée Delem , Eric d'Hondt , Francis E. André
DOI: 10.1016/S0022-3476(85)80123-2
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摘要: In a randomized, double-blind, placebo-controlled trial, 331 infants aged 6 to 12 months received orally, at an interval of 1 month, either two doses live attenuated bovine rotavirus vaccine strain RIT 4237 or equivalent placebo. The vaccinations were carried out during September November, non-rotavirus season; only three cases diarrhea occurred in the study group before completed. During epidemic season from December May, 31 patients with clinically significant required fluid therapy. Five these among 168 recipients, and 26 160 placebo recipients (P
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