Modifications of peptide compositions to increase stability and delivery efficiency
作者： Derek Maclean
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摘要: The disclosed invention relates to methods of modifying peptide compositions increase stability and delivery efficiency. Specifically, the efficiency protein kinase C (PKC) modulatory compositions. A “therapeutic composition” comprises a “carrier peptide” “cargo peptide.” is or amino acid sequence within that facilitates cellular uptake therapeutic composition. PKC peptide. Peptide modifications either carrier peptide, cargo both, which are described herein by reducing disulfide bond exchange, physical stability, proteolytic degradation, increasing uptake.
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