Label free analyte detection by electronic desalting and field effect transistors

摘要: Provided are methods and devices for the label free detection of analytes in solution, including suspended a biological fluid. A field effect transistor (FET) is positioned close proximity to paired set reference electrodes electrically biased provide desalting stable gate voltage FET. In this manner, charged ions depleted sensing region sensor device sensitivity analyte improved by removal charge that otherwise interferes with measurement. Also provided systems providing increased electrode surface area and/or decrease droplet volume further improve label-free analytes.