Enhanced Levels of Soluble and Membrane-Bound CD40 Ligand in Patients With Unstable Angina Possible Reflection of T Lymphocyte and Platelet Involvement in the Pathogenesis of Acute Coronary Syndromes

作者: Pål Aukrust , Fredrik Müller , Thor Ueland , Trude Berget , Elinor Aaser

DOI: 10.1161/01.CIR.100.6.614

关键词:

摘要: Background—The CD40 ligand (CD40L) on activated T cells and platelets may be activating matrix metalloproteinases, inducing procoagulant activity, involved in the pathogenesis of acute coron...

参考文章(36)
A. C. Grammer, P. E. Lipsky, Laurie S Davis, Y. Miura, K. Fujita, M. C. Bergman, The CD40 ligand expressed by human B cells costimulates B cell responses. Journal of Immunology. ,vol. 154, pp. 4996- 5010 ,(1995)
Einar Martin Aandahl, Pål Aukrust, Bj⊘rn S. Skålhegg, Fredrik Müller, Stig S. Fr⊘land, Vidar Hansson, Kjetil Taskén, Protein kinase A type I antagonist restores immune responses of T cells from HIV-infected patients The FASEB Journal. ,vol. 12, pp. 855- 862 ,(1998) , 10.1096/FASEBJ.12.10.855
Ling Zhou, Patrick Stordeur, Aurore de Lavareille, Kris Thielemans, Paul Capel, Michel Goldman, Olivier Pradier, CD40 engagement on endothelial cells promotes tissue factor-dependent procoagulant activity. Thrombosis and Haemostasis. ,vol. 79, pp. 1025- 1028 ,(1998) , 10.1055/S-0037-1615114
D. Hollenbaugh, L.S. Grosmaire, C.D. Kullas, N.J. Chalupny, S. Braesch-Andersen, R.J. Noelle, I. Stamenkovic, J.A. Ledbetter, A. Aruffo, The human T cell antigen gp39, a member of the TNF gene family, is a ligand for the CD40 receptor: expression of a soluble form of gp39 with B cell co-stimulatory activity. The EMBO Journal. ,vol. 11, pp. 4313- 4321 ,(1992) , 10.1002/J.1460-2075.1992.TB05530.X
Volker Henn, Joseph R. Slupsky, Michael Gräfe, Ioannis Anagnostopoulos, Reinhold Förster, Gert Müller-Berghaus, Richard A. Kroczek, CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells Nature. ,vol. 391, pp. 591- 594 ,(1998) , 10.1038/35393
A Aruffo, D Hollenbaugh, P A Kiener, A F Wahl, P Moran-Davis, B M Rankin, Stimulation of CD40 with purified soluble gp39 induces proinflammatory responses in human monocytes Journal of Immunology. ,vol. 155, pp. 4917- 4925 ,(1995)
Joseph A. Francisco, Peter A. Kiener, Clay B. Siegall, Patricia Moran-Davis, Jeffrey A. Ledbetter, Cytokine activation sensitizes human monocytic and endothelial cells to the cytotoxic effects of an anti-CD40 immunotoxin. Journal of Immunology. ,vol. 157, pp. 1652- 1658 ,(1996)
P Sarén, H G Welgus, P T Kovanen, TNF-alpha and IL-1beta selectively induce expression of 92-kDa gelatinase by human macrophages. Journal of Immunology. ,vol. 157, pp. 4159- 4165 ,(1996)
Edward A. Clark, William C. Fanslow, Stephen J. Klaus, Che Leung Law, Richard J. Armitage, Hans D. Ochs, Lesya M. Pinchuk, Costimulation through CD28 enhances T cell-dependent B cell activation via CD40-CD40L interaction. Journal of Immunology. ,vol. 152, pp. 5643- 5652 ,(1994)