Polyclonal gamma delta t cells for immunotherapy
作者： Drew C. Deniger , Laurence J.N. Cooper
DOI:
关键词:
摘要: Provided herein is a method of expanding clinically-relevant quantities polyclonal γδ T cells that have anti-tumor, anti-viral, and anti-bacterial reactivity. Polyclonal can target variety tumors, including solid tumors as well other conditions, such viral bacterial infections.
lens.org 参考文章(16)
Drew C Deniger, T-CELL TREATMENTS FOR SOLID AND HEMATOLOGICAL TUMORS ,(2013)
Daniel Vargas Correia, Bruno Miguel de Carvalho e Silva Santos, Cell line of lymphocytes comprising gamma-delta t cells, composition and production method thereof ,(2012)
Ekta Samir Patel, Lung-Ji Chang, System and method for producing t cells ,(2009)
Nicole Aqui, Carl H. June, Megan M. Suhoski, James L. Riley, Robert H. Vonderheide, Novel artificial antigen presenting cells and uses therefor ,(2005)
Carl June, Marcela Maus, James Riley, Anna Thomas, Robert Vonderheide, Activation and expansion of T-cells using an engineered multivalent signaling platform ,(2003)
Hiroki Torikai, Laurence J. Neil Cooper, Car+ t cells genetically modified to eliminate expression of t-cell receptor and/or hla ,(2012)
Kim Wieties Clary, David C. Flyer, Modified rapid expansion methods ('modified-rem') for in vitro propagation of t lymphocytes ,(1997)
Juli Degraw, Zeling Cai, Karen Kabat Stegman, Xilian Yue, Wei-Xing Shi, Ann Moriarty, Didier Leturcq, Preparation of inactivated artificial antigen presenting cells and their use in cell therapies ,(2007)
Drew C Deniger, Kirsten Switzer, Tiejuan Mi, Sourindra Maiti, Lenka Hurton, Harjeet Singh, Helen Huls, Simon Olivares, Dean A Lee, Richard E Champlin, Laurence JN Cooper, Bispecific T-cells Expressing Polyclonal Repertoire of Endogenous γδ T-cell Receptors and Introduced CD19-specific Chimeric Antigen Receptor Molecular Therapy. ,vol. 21, pp. 638- 647 ,(2013) , 10.1038/MT.2012.267
Daniel V. Correia, Manuela Fogli, Kelly Hudspeth, Maria Gomes da Silva, Domenico Mavilio, Bruno Silva-Santos, Differentiation of human peripheral blood Vδ1+ T cells expressing the natural cytotoxicity receptor NKp30 for recognition of lymphoid leukemia cells Blood. ,vol. 118, pp. 992- 1001 ,(2011) , 10.1182/BLOOD-2011-02-339135