Modified gamma delta t cells and uses thereof
作者： Adele Hannigan , Michael David Leek , Daria Paruzina , Agapitos Patakas
DOI:
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摘要: The present invention provides composition and methods for the treatment of cancer or infectious diseases in a human. includes generation administration gamma delta ? cells that express chimeric antigen receptors (CARs) comprising an binding domain, hinge transmembrane costimulatory signalling domain with inclusion not CD3 zeta domain. Expression CAR sequence omitting T cells, CAR-T therapy vivo, which will effect cytolysis only on target providing ligands activation cell receptor (TCR).
lens.org 参考文章(37)
Volker Kunzmann, Eva Bauer, Juliane Feurle, Florian Weißinger, Hans-Peter Tony, Martin Wilhelm, Stimulation of γδ T cells by aminobisphosphonates and induction of antiplasma cell activity in multiple myeloma Blood. ,vol. 96, pp. 384- 392 ,(2000) , 10.1182/BLOOD.V96.2.384
Carl H. June, Daniel J. Powell, Use of a trans-signaling approach in chimeric antigen receptors ,(2013)
Michael Jensen, Bispecific chimeric antigen receptors and therapeutic uses thereof ,(2013)
M. WALLACE, S. R. BARTZ, W.‐L. CHANG, D. A. MACKENZIE, C. D. PAUZA, M. MALKOVSKY, γδ T lymphocyte responses to HIV Clinical and Experimental Immunology. ,vol. 103, pp. 177- 184 ,(1996) , 10.1046/J.1365-2249.1996.D01-625.X
Yoshimasa Tanaka, Craig T. Morita, Yoko Tanaka, Edward Nieves, Michael B. Brenner, Barry R. Bloom, Natural and synthetic non-peptide antigens recognized by human γδ T cells Nature. ,vol. 375, pp. 155- 158 ,(1995) , 10.1038/375155A0
Adrienne H Long, Waleed M Haso, Jack F Shern, Kelsey M Wanhainen, Meera Murgai, Maria Ingaramo, Jillian P Smith, Alec J Walker, M Eric Kohler, Vikas R Venkateshwara, Rosandra N Kaplan, George H Patterson, Terry J Fry, Rimas J Orentas, Crystal L Mackall, 4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors Nature Medicine. ,vol. 21, pp. 581- 590 ,(2015) , 10.1038/NM.3838
Jordan Jarjour, Alexander Astrakhan, Michael Certo, Multipartite signaling proteins and uses thereof ,(2014)
Oliver Nussbaumer, Georg Gruenbacher, Hubert Gander, Juliana Komuczki, Andrea Rahm, Martin Thurnher, Essential requirements of zoledronate-induced cytokine and γδ T cell proliferative responses. Journal of Immunology. ,vol. 191, pp. 1346- 1355 ,(2013) , 10.4049/JIMMUNOL.1300603
A J Nicol, H Tokuyama, S R Mattarollo, T Hagi, K Suzuki, K Yokokawa, M Nieda, Clinical evaluation of autologous gamma delta T cell-based immunotherapy for metastatic solid tumours. British Journal of Cancer. ,vol. 105, pp. 778- 786 ,(2011) , 10.1038/BJC.2011.293
Drew C Deniger, Kirsten Switzer, Tiejuan Mi, Sourindra Maiti, Lenka Hurton, Harjeet Singh, Helen Huls, Simon Olivares, Dean A Lee, Richard E Champlin, Laurence JN Cooper, Bispecific T-cells Expressing Polyclonal Repertoire of Endogenous γδ T-cell Receptors and Introduced CD19-specific Chimeric Antigen Receptor Molecular Therapy. ,vol. 21, pp. 638- 647 ,(2013) , 10.1038/MT.2012.267