Deconvolution-based CT and MR brain perfusion measurement: theoretical model revisited and practical implementation details

摘要: Deconvolution-based analysis of CT and MR brain perfusion data is widely used in clinical practice it still a topic ongoing research activities. In this paper, we present comprehensive derivation explanation the underlying physiological model for intravascular tracer systems. We also discuss practical details that are needed to properly implement algorithms analysis. Our description computer implementation focused on most frequently employed algebraic deconvolution methods based singular value decomposition. particular, further need regularization order obtain physiologically reasonable results. include an overview relevant preprocessing steps provide numerous references literature. cover both imaging paper because they share many common aspects. The combination theoretical as well aspects explicitly emphasizes simplifications physiologicalmodel necessary apply measured acquired with current scanners.