THE ACTION OF TETRACYCLINE AND CHLORAMPHENICOL ALONE AND IN ADMIXTURE ON THE GROWTH OF ESCHERICHIA COLI*

作者: Edward R. Garrett , M. R. W. Brown

DOI: 10.1111/J.2042-7158.1963.TB11210.X

关键词:

摘要: The dependence of E. coli growth rates upon chloramphenicol concentration has been established. Chloramphenicol and tetracycline are equivalent in their action on combined effects rate additive. decrease is a function the first power either antibiotic or combinations them. A new mechanism implied when decreases to negative values: at this stage fractional concentration.

参考文章(3)
Gertrude B. Elion, Samuel Singer, George H. Hitchings, Antagonists of nucleic acid derivatives. VIII. Synergism in combinations of biochemically related antimetabolites. Journal of Biological Chemistry. ,vol. 208, pp. 477- 488 ,(1954) , 10.1016/S0021-9258(18)65573-5
Jennie Ciak, Fred E. Hahn, MECHANISMS OF ACTION OF ANTIBIOTICS I. Escherichia coli Journal of Bacteriology. ,vol. 75, pp. 125- 129 ,(1958) , 10.1128/JB.75.2.125-129.1958
Garrett Er, Classification and evaluation of combined antibiotic activity. Antibiotics and Chemotherapy. ,vol. 8, pp. 8- 20 ,(1958)