Metabolic risk factors in a cohort of young adults and their association with a body-mass index between 22 and 25kg/m2

摘要: Abstract Background and objectives Although health risks associated to excessive body fat increase with small increases in weight, measurement of is usually grouped very few categories. The aim our study was assess whether the risk for a combined end-point including incidence either hypertension and/or type 2 diabetes mellitus metabolic syndrome elevated even within “normal” limits body-mass index (BMI). Material methods We followed up 10,639 initially healthy university graduates participating SUN dynamic cohort variable period ranging 6 years. Baseline BMI physical activity were major exposures. defined by during follow-up period. fitted non-conditional logistic regression models nonparametric (restricted cubic splines). Results observed 768 incident cases outcome (incidence 16/1000 person-years) found monotonic linear association between end-point. multivariate-adjusted odds ratios 1.4 (95% CI: 1.1–1.7) 22–24.9 kg/m , 2.7 (2.1–3.5) 25–29.9 kg/m 4.0 (2.8–5.6) ⩾30 kg/m . threshold effect ratio=0.8 (0.7–0.9) >15 METs-h/week. Conclusions Our findings suggest that factors (hypertension, syndrome) already increased at 22 kg/m young adults. These results deserve consideration judging cut-off point weight should be lowered.