Binding patterns of immunoglobulins from tumor-bearing mice to the corresponding tumor cells

摘要: Abstract In this study we report on measurements to determine the binding constants of immunoglobulins tumor cells. IgG from normal and tumor-bearing mice was studied. It found that preparations SEYF-a (a syngeneic polyoma-virus-induced ascites tumor)-bearing contain at least two distinct populations molecules which differ one another with respect their One population is characterized by a high constant cells, while second reveals much lower these Normal mouse also bind however, low. Soluble antigens extracted corresponding cells were able inhibit specifically originating mice, exhibited Antigens non-related tissues did not affect patterns Moreover, prepared SEYF-a-bearing only when interacted but non-corresponding ones. These results suggest fraction composed mainly antibodies surface Determination anti-tumor could prove useful as an additional method for determinations degree serological relations between various tumors further characterization antibodies.