Biomarkers of susceptibility following benzene exposure: influence of genetic polymorphisms on benzene metabolism and health effects
作者： Damiano Carbonari , Pieranna Chiarella , Antonella Mansi , Daniela Pigini , Sergio Iavicoli
DOI: 10.2217/BMM.15.106
关键词:
摘要: Benzene is a ubiquitous occupational and environmental pollutant. Improved industrial hygiene allowed airborne concentrations close to the context (1–1000 µg/m3). Conversely, new limits for benzene levels in urban air were set (5 The biomonitoring of exposure such low are performed measuring specific sensitive biomarkers as S-phenylmercapturic acid, trans, trans-muconic acid urinary benzene: many studies referred high variability these biomarkers, suggesting involvement polymorphic metabolic genes individual susceptibility toxicity. We reviewed influence polymorphisms on effect, order understand real impact subjects with increased susceptibility.
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