Synthesis, interaction with DNA and bovine serum albumin of the transition metal complexes of demethylcantharate and 2-aminobenzothiazole.

摘要: Four new transition metal complexes (Habtz) 2 [M(DCA) ]·6H O (M = Co(II) ( 1 ), Ni(II) Cu(II) 3 Zn(II) 4 ); DCA = demethylcantharate, 7-oxabicyclo [2.2.1]heptane-2,3-dicarboxylate, C 8 H 5 ; Habtz = 2-aminobenzothiazole acid, 7 N S) were synthesized and characterized by elemental analysis, molar conductance, infrared spectra thermogravimetric analysis. The coordination number of complex was six. X-ray diffraction analysis indicated that crystallized in the triclinic crystal system with P ¯ space group. DNA-binding properties investigated electronic absorption spectra, fluorescence viscosity measurements. Title could bind to DNA via partial intercalative mode. K b 5.33 × 10 7.04 × 10 9.91 × 10 ) 5.03 × 10  L mol −1 ). results agarose gel electrophoresis showed cleave pBR322 plasmid radical-based mechanism. quench intrinsic bovine serum albumin (BSA) through a static quenching binding constants 1.11 × 10 1.24 × 10 6 2) , 8.42 × 10 1.75 × 10 had intense antiproliferative activities against human hepatoma cell lines (SMMC7721) gastric cancer cells (MGC80-3) vitro . strongest activity cells.