[Genetic basis of Cushing's disease in children and targeted therapeutic future perspectives].

摘要: Cushing's disease (CD) is a multisystem disorder of cortisol excess caused by ACTH -secreting pituitary tumor (corticotropinoma). CD in children due to somatic or germline mutations with the late onset causing multiple endocrine tumors. If not treated, hypercortisolism leads severe decrease quality life and life-threating conditions. The first-line treatment for surgery, which might be followed complications relapse necessity additional surgery initiations second-line treatment. Recent studies molecular basis corticotropinoma development made it possible employ medical therapy CD. Understanding etiology pathogenesis an important part education pediatric endocrinologists since we need keep mind possibility case because gain more role future.The most actual genetic aspects corticotroph adenomas growth opportunities are present this review.