The titration curve of weak polyacids

摘要: A simplified model of the titration curve weak polyacids is presented, based on a combination limiting law expressions for extent counterion binding and nearest-neighbor interactions among titrated sites polyion. Expressions are derived intrinsic acid dissociation constant anticooperativity that can be related to experimental data in middle curve, region readily accessible by experiment, so avoiding extrapolation into regions where hard collect or errors magnified. The shape salt dependence quantitatively predicted very simply our