P2 receptors in atherosclerosis and postangioplasty restenosis
作者： Cheikh I. Seye , Qiongman Kong , Ningpu Yu , Fernando A. Gonzalez , Laurie Erb
DOI: 10.1007/S11302-006-9047-6
关键词:
摘要: Atherosclerosis is an immunoinflammatory process that involves complex interactions between the vessel wall and blood components thought to be initiated by endothelial dysfunction [1–3]. Extracellular nucleotides are released from a variety of arterial cells [4] can bind P2 receptors modulate proliferation migration smooth muscle (SMC), which known involved in intimal hyperplasia accompanies atherosclerosis postangioplasty restenosis [5]. In addition, mediate many other functions, including platelet aggregation, leukocyte adherence, vasomotoricity. A direct pathological role reinforced recent evidence showing up-regulation activation P2Y2 rabbit arteries mediates [6]. functional P2Y also has been demonstrated basilar artery rat double-hemorrhage model [7] coronary diabetic dyslipidemic pigs [8]. It proposed may potential diagnostic indicator for early stages [9]. Therefore, particular effort must made understand consequences nucleotide release cardiovascular system subsequent effects receptor vessels, reveal novel therapeutic strategies after angioplasty.
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