Human neutrophil peptides: a novel potential mediator of inflammatory cardiovascular diseases.

摘要: The traditional view of atherosclerosis has recently been expanded from a predominantly lipid retentive disease to coupling inflammatory mechanisms and dyslipidemia. Studies have suggested novel role for polymorphonuclear neutrophil (PMN)-dominant inflammation in the development atherosclerosis. Human peptides (HNPs), also known as α-defensins, are secreted released PMN granules upon activation conventionally involved microbial killing. Current evidence suggests an important immunomodulative these peptides. HNP levels markedly increased diseases including sepsis acute coronary syndromes. They found within intima human atherosclerotic arteries, their deposition skin correlates with severity artery diseases. HNPs form complexes LDL solution increase binding endothelial surface. shown contribute dysfunction, metabolism disorder, inhibition fibrinolysis. Given emerging relationship between PMN-dominant atherosclerosis, may serve link them biological marker potential therapeutic target cardiovascular