Sickle cell bone disease: response to vitamin D and calcium.
作者： Adeboye H. Adewoye , Tai C. Chen , Qianli Ma , Lillian McMahon , Jeff Mathieu
DOI: 10.1002/AJH.21085
关键词:
摘要: Bone disease with osteoporosis and osteomalacia are common in sickle cell (SCD). Some patients have vitamin D deficiency low bone mineral density (BMD). The role of calcium supplementation to restore health SCD has not been well studied. In 14 adults SCD, we measured 25(OH)D (25-hydroxyvitamin D) BMD at the femoral neck, lumbar spine, distal third ulna plus radius, along markers resorption (CTx; C-terminal component pro-collagen type I) formation (osteocalcin) before after 12 months D(2) carbonate treatment. Pretreatment, all were deficient a mean level 11.6 [corrected] +/- 4 ng/ml, had spine (L-spine), 0.87 0.11 g/cm(2) (mean Z-score -2.6 3 0.71 SD T score -2.31 0.75 SD), 0.8 0.18 -1.36 0.84, T-score -1.14 0.75), radius ulna, 0.6 0.17 -1.18 0.79, -1.01 0.74) elevated CTx (0.87 0.5 ng/ml) osteocalcin levels (12.3 3.7 ng/mul). After treatment, corrected their (34.6 11 (P < 0.001) 3.6% 3.9% increase L-spine = 0.009), 4.6% 8.5% neck 0.05) 6.5% 12.6% 0.09). CTx, osteocalcin, PTH(i) unchanged. Treatment adult can normal improve BMD, but, remained Screening for seems warranted.
sci-hub.se 参考文章(40)
Maria E. Street, Cinzia Spaggiari, Maria A. Ziveri, Cecilia Volta, Giovanni Federico, Giampiero I. Baroncelli, Sergio Bernasconi, Giuseppe Saggese, Analysis of bone mineral density and turnover in patients with cystic fibrosis: associations between the IGF system and inflammatory cytokines. Hormone Research in Paediatrics. ,vol. 66, pp. 162- 168 ,(2006) , 10.1159/000094143
Vikki G. Nolan, Adeboye Adewoye, Clinton Baldwin, Ling Wang, Qianli Ma, Diego F. Wyszynski, John J. Farrell, Paola Sebastiani, Lindsay A. Farrer, Martin H. Steinberg, Sickle cell leg ulcers: associations with haemolysis and SNPs in Klotho, TEK and genes of the TGF-beta/BMP pathway. British Journal of Haematology. ,vol. 133, pp. 570- 578 ,(2006) , 10.1111/J.1365-2141.2006.06074.X
A.C Looker, B Dawson-Hughes, M.S Calvo, E.W Gunter, N.R Sahyoun, Serum 25-hydroxyvitamin D status of adolescents and adults in two seasonal subpopulations from NHANES III. Bone. ,vol. 30, pp. 771- 777 ,(2002) , 10.1016/S8756-3282(02)00692-0
LUIS R. ESPINOZA, I. SPILBERG, C. K. OSTERLAND, Joint manifestations of sickle cell disease. Medicine. ,vol. 53, pp. 295- 305 ,(1974) , 10.1097/00005792-197407000-00003
Vin Tangpricha, Elizabeth N. Pearce, Tai C. Chen, Michael F. Holick, Vitamin D insufficiency among free-living healthy young adults The American Journal of Medicine. ,vol. 112, pp. 659- 662 ,(2002) , 10.1016/S0002-9343(02)01091-4
Sanford Baim, Mary B. Leonard, Maria-Luisa Bianchi, Didier B. Hans, Heidi J. Kalkwarf, Craig B. Langman, Frank Rauch, Official Positions of the International Society for Clinical Densitometry and Executive Summary of the 2007 ISCD Pediatric Position Development Conference Journal of Clinical Densitometry. ,vol. 11, pp. 6- 21 ,(2006) , 10.1016/J.JOCD.2007.12.002
MONA S. CALVO, DAVID R. EYRE, CAREN M. GUNDBERG, Molecular Basis and Clinical Application of Biological Markers of Bone Turnover Endocrine Reviews. ,vol. 17, pp. 333- 368 ,(1996) , 10.1210/EDRV-17-4-333
Gregory J. Kato, Mark T. Gladwin, Martin H. Steinberg, Deconstructing sickle cell disease: Reappraisal of the role of hemolysis in the development of clinical subphenotypes Blood Reviews. ,vol. 21, pp. 37- 47 ,(2007) , 10.1016/J.BLRE.2006.07.001
Ashraf T Soliman, Haddia Bererhi, Assim Darwish, Mahmoud M Alzalabani, Yasser Wali, Behjat Ansari, Decreased Bone Mineral Density in Prepubertal Children with Sickle Cell Disease: Correlation with Growth Parameters, Degree of Siderosis and Secretion of Growth Factors Journal of Tropical Pediatrics. ,vol. 44, pp. 194- 198 ,(1998) , 10.1093/TROPEJ/44.4.194
T.L. Clemens, S.L. Henderson, J.S. Adams, M.F. Holick, Increased skin pigment reduces the capacity of skin to synthesise vitamin D3. The Lancet. ,vol. 319, pp. 74- 76 ,(1982) , 10.1016/S0140-6736(82)90214-8