Bone Status in Patients with Sickle Cell Disease: A Case Control Study

摘要: Objectives (background): Both sickle cell disease and vitamin D deficiency are common among Saudi population. The present work asses Parathyroid hormone/Vitamin axis as well bone dynamics in young adults with disease.Methods: A case control study includes forty patients known to have from the outpatient clinics of North Western Armed Forces Hospital, Tabuk were randomly selected for study. Another 120 healthy individuals involved control. Cases subjected full history taking, clinical examination, radiologic laboratory investigations.Results: Bone image revealed diffuse osteopenia 16 (40%) cases, avascular necrosis femoral head 6 (15%), code fish vertebral bodies (15%) coarse trabecular pattern (15%). Laboratory investigations hypocalcemia 18 (45%), secondary hyperparathyroidism 24 (60%), non-detectable 30 (75%) detectable but subnormal 10 (25%). mean level serum calcium cases was significantly less than that (p < 0.001).. intact hormone higher 0.001). Serum 25-hydroxyvitamin lower studied For Specific Alkaline Phosphatase 0.001).Conclusion: Vitamin though a finding it is more severe subsequent frequent hypocalcemia.