High prevalence and correlates of low bone mineral density in young adults with sickle cell disease

摘要: Sickle cell disease (SCD) is a prevalent genetic disorder in which sickle hemoglobin leads to tissue hypoxia and adverse effects on bone. Published studies suggest that children with SCD often have undiagnosed osteopenia or osteoporosis. Minimal data exist the prevalence of low bone mineral density (BMD) adults. Our objective was describe osteoporosis adults identify patient characteristics associated BMD. We conducted cross-sectional study SCD. Through questionnaires, we collected about course risk factors. Patients underwent dual X-ray absorptiometry (DXA) measurement BMD at hip, spine, forearm sampling blood urine for markers turnover, severity, secondary causes main outcome measure as defined by WHO criteria. Of 32 (14 men 18 women) mean age 34 years, 72% (95% confidence interval 53-86%) had one more anatomic sites. Thirteen patients were classified osteoporotic 10 osteopenic. The greatest lumbar spine (66% patients). Significant correlates decreased included BMI (P < 0.01), male sex = 0.02), serum zinc concentrations 0.01). young extremely high. Further research needed address fracture therapeutic interventions.