Morbidity in survivors of child and adolescent meningioma

摘要: BACKGROUND The extent of initial surgical resection has been identified as the strongest prognostic indicator for survival in child and adolescent meningioma. Given paucity data concerning long-term outcome, authors undertook a meta-analysis to analyze morbidity survivors this disease. METHODS Individual patient were obtained from 19 case series published over last 23 years through direct communication with authors. Ordinal logistic regression models used assess influence risk factors on morbidity. RESULTS Of 261 patients, 48% reported completely normal life no morbidity, 25% had moderate/severe meningioma-associated at follow-up. Multivariate analysis relapse only independent variable associated an increased (odds ratio, 4.02; 95% confidence interval, 2.11-7.65; P ≤ .001). Univariate also revealed patients neurofibromatosis 1.90; 1.04-3.48; P = .04). Subgroup higher incidence among who intracranial tumors skull base location compared nonskull (P ≤ .001). Timing which occurred was available 70 persistence preoperative tumor-related symptoms 67% result therapy 20%. CONCLUSIONS The majority meningioma or mild whereas significantly relapsed disease. In majority, consequence tumor itself, justifying aggressive surgery achieve gross total resection. However, meningioma, more cautious approach should be reserved. Cancer 2013;119:4350–4357. © 2013 The Authors. by Wiley Periodicals, Inc. behalf American Society.