Maternal, fetal, and neonatal parameters for prognosis and counseling of HCMV congenital infection

摘要: To investigate retrospectively the prognostic significance of maternal, fetal, and neonatal parameters clinical outcome in 150 HCMV congenital infections during period 1995–2009. fetal infection was investigated amniotic fluid blood samples. confirmed newborn urine Symptomatic defined HCMV-infected fetuses infected newborns on basis physical instrumental findings. Follow-up at 3, 6, 12 months, then annually up to school age, included evaluation, funduscopic, audiologic, neurologic, cognitive assessment. Overall, 122/150 (81.3%) were asymptomatic 28/150 (18.7%) symptomatic birth. The best maternal parameter birth gestational age (P = 0.037). virological markers DNA levels (P < 0.001), antigenaemia (P = 0.007), (P = 0.004), HCMV-specific IgM index values (P = 0.002). only significant level [P = 0.006; OR, 3.62 (95% CI, 1.46–8.97)]. Symptoms correlated significantly with long-term sequelae (P = 0.021). A trend towards a risk early (n = 15/58 examined) versus late (n = 6/57 documented. increased linearly number parameters. J. Med. Virol. 86:2163–2170, 2014. © 2014 Wiley Periodicals, Inc.