Acetaldehyde dehydrogenase 2 (ALDH2) activation protects hepatocytes from mitochondrial damage and death caused by 4-hydroxynonenal.

作者: Keegan Baldauf

DOI: 10.18297/ETD/63

关键词:

摘要:

参考文章(44)
Per O. Seglen, Preparation of isolated rat liver cells. Methods in Cell Biology. ,vol. 13, pp. 29- 83 ,(1976) , 10.1016/S0091-679X(08)61797-5
Satori A Marchitti, Chad Brocker, Dimitrios Stagos, Vasilis Vasiliou, Non-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamily. Expert Opinion on Drug Metabolism & Toxicology. ,vol. 4, pp. 697- 720 ,(2008) , 10.1517/17425255.4.6.697
Chisato Murata, Tetsu Watanabe, Hiroyuki Furuya, Yoshihiko Sugioka, Hajime Mikurube, Akira Yokoyama, Yoshihito Atsumi, Kempei Matsuoka, Isao Okazaki, Aldehyde dehydrogenase 2 and β3-Adrenergic receptor gene polymorphisms: Their association with elevated liver enzymes and metabolic syndrome Metabolism-clinical and Experimental. ,vol. 52, pp. 1096- 1101 ,(2003) , 10.1016/S0026-0495(03)00183-5
Vasilis Vasiliou, Aglaia Pappa, Dennis R Petersen, Role of aldehyde dehydrogenases in endogenous and xenobiotic metabolism. Chemico-Biological Interactions. ,vol. 129, pp. 1- 19 ,(2000) , 10.1016/S0009-2797(00)00211-8
Kyoko Kitagawa, Toshihiro Kawamoto, Naoki Kunugita, Tadasuke Tsukiyama, Kohji Okamoto, Akira Yoshida, Keiko Nakayama, Kei-ichi Nakayama, Aldehyde dehydrogenase (ALDH) 2 associates with oxidation of methoxyacetaldehyde; in vitro analysis with liver subcellular fraction derived from human and Aldh2 gene targeting mouse. FEBS Letters. ,vol. 476, pp. 306- 311 ,(2000) , 10.1016/S0014-5793(00)01710-5
Bridget Grant, Mary Dufour, Thomas Harford, Epidemiology of alcoholic liver disease. Seminars in Liver Disease. ,vol. 8, pp. 12- 25 ,(1988) , 10.1055/S-2008-1040525
Matteo Beretta, Karl Gruber, Alexander Kollau, Michael Russwurm, Doris Koesling, Walter Goessler, Wing Ming Keung, Kurt Schmidt, Bernd Mayer, Bioactivation of nitroglycerin by purified mitochondrial and cytosolic aldehyde dehydrogenases. Journal of Biological Chemistry. ,vol. 283, pp. 17873- 17880 ,(2008) , 10.1074/JBC.M801182200
Edward D. Lowe, Guang-Yao Gao, Louise N. Johnson, Wing Ming Keung, Structure of daidzin, a naturally occurring anti-alcohol-addiction agent, in complex with human mitochondrial aldehyde dehydrogenase. Journal of Medicinal Chemistry. ,vol. 51, pp. 4482- 4487 ,(2008) , 10.1021/JM800488J
P. J. O’Brien, W. Irwin, D. Diaz, E. Howard-Cofield, C. M. Krejsa, M. R. Slaughter, B. Gao, N. Kaludercic, A. Angeline, P. Bernardi, P. Brain, C. Hougham, High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening. Archives of Toxicology. ,vol. 80, pp. 580- 604 ,(2006) , 10.1007/S00204-006-0091-3