Aldehyde dehydrogenase 2 and β3-Adrenergic receptor gene polymorphisms: Their association with elevated liver enzymes and metabolic syndrome

摘要: Recent studies indicate that some patients with nonalcoholic fatty liver have ongoing injury may progress from steatosis to steatohepatitis or fibrosis. The present study was designed clarify the clinical features of dysfunction observed in course workplace physical check-ups relation multiple risk factor syndrome including obesity, hyperlipidemia, hypertension, and impaired glucose tolerance, involvement aldehyde dehydrogenase 2 (ALDH2) beta(3)-adrenergic receptor (beta3-AR) gene polymorphisms elevation enzymes. One hundred forty-eight male workers 35 years age were enrolled. They requested answer questionnaires about drinking smoking habits, underwent urinalysis, peripheral blood examinations, chemistry, electrocardiogram chest x-rays. genotypes ALDH2 beta3-AR analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). subjects divided into active inactive groups. also groups according genotype. relationships between results examination function tests analyzed. number components metabolic syndrome. prevalence elevated alanine aminotransferase (ALT) level increased accumulation Active associated ALT a greater degree than polymorphism. Among those normal body mass index (BMI), strongly level. Logistic regression analysis revealed BMI, triglyceride level, genotype elevation. In conclusion, evaluating assist predicting preventing development which be related