Clinical features of nonalcoholic steatohepatitis in Japan : evidence from the literature

摘要: Metabolic syndrome, that is, obesity, hypertension, hyperlipidemia, and insulin resistance with hyperinsulinemia, is a new disease entity prevailing worldwide, nonalcoholic steatohepatitis (NASH) believed to be hepatic expression of this syndrome. NASH characterized by zone 3-dominant steatosis ballooned hepatocytes Mallory bodies, 3 pericellular perivenular fibrosis or without bridging fibrosis, lobular inflammatory cell infiltration. Indeed, 90% has been revealed complicated visceral two-thirds patients fulfill the criteria metabolic Therefore, variety lifestyle-related diseases such as diabetes mellitus may share same background. most prevalent well in Caucasians; however, little known about its occurrence Asia-Oceania, because obesity not frequent countries these areas. Obesity expected become serious social problem Asia-Oceania next two decades, so we need prevent corresponding increase NASH. For purpose, know much only but also ourselves. To elucidate status Japan, recent progress study Japan reviewed article.