Association of a Polymorphism in the β3-Adrenergic–Receptor Gene with Features of the Insulin Resistance Syndrome in Finns
作者： Elisabeth Widén , Markku Lehto , Timo Kanninen , Jeremy Walston , Alan R. Shuldiner
DOI: 10.1056/NEJM199508103330604
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摘要: Background Because visceral obesity predicts insulin resistance, we studied whether alterations in the gene encoding for β3-adrenergic receptor fat are associated with resistance. Methods We frequency of a cytosine-to-thymidine mutation that results replacement tryptophan by arginine at position 64 (Trp64Arg) restriction-enzyme digestion BstOI 335 subjects from western Finland, 207 whom were nondiabetic and 128 had non-insulin-dependent diabetes mellitus (NIDDM). also determined 156 southern Finland. Sensitivity to was measured hyperinsulinemic–euglycemic clamp technique 66 randomly selected subjects. Results In mutated allele similar NIDDM (12 vs. 11 percent). The mean age onset lowe...
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