A Mutation in the β3-Adrenergic Receptor Gene Is Associated with Obesity and Hyperinsulinemia in Japanese Subjects

摘要: The Trp 64 Arg mutation in the beta 3-adrenergic receptor (beta 3AR) gene was investigated 350 Japanese subjects. This not associated with non-insulin-dependent diabetes mellitus (NIDDM). In 191 subjects without NIDDM, body mass index (BMI) significantly higher homozygous for this than those normal allele (24.7 +/- 1.4 vs 22.1 0.2 kg/m2, p = 0.009). Moreover, frequency of mutant obese (BMI > 26.4) that non-obese < 22) (0.37 0.15, presence also accompanied by fasting (p 0.000) and 2 hrs 0.018) serum insulin levels during an oral glucose tolerance test. 3AR may be one loci contributing to obesity hyperinsulinemia/insulin resistance