Change of components of the metabolic syndrome in a workers' health checkup after five years--relation with elevated liver enzymes, gene polymorphisms for ALDH 2, beta3-AR and lifestyle.

摘要: We previously reported that the prevalence of elevated alanine aminotransferase (ALT) increases with accumulation metabolic syndrome components, and a greater degree involvement aldehyde dehydrogenase 2 (ALDH2) than beta3-adrenergic receptor gene (beta3-AR) polymorphisms. The present study was designed to clarify effect aging, lifestyle two polymorphisms on relationship between 4 components (obesity, hypertension, dyslipidemia impaired glucose tolerance) ALT values in subset 73 out 148 male workers who were 35 years age baseline 40 old study. Study subjects completed questionnaires about drinking smoking habits, underwent urinalysis, physical examination peripheral blood tests, chemistry, electrocardiogram chest X-rays each year as required by Japanese law. Information from examinations, including liver function compared ALDH2 beta3-AR genotypes for workers. Of studied, 14 (19%) demonstrated decrease 39 (53%) no change, 20 (27%) an increase. Ten (14%) showed dysfunction at 40. Fourteen newly diagnosed having their 40-year checkup, thus being associated BMI active genotype. Accumulation presence years. In conclusion, these findings indicate genotyping well habits may be important factors causing dysfunction.