In vitro reversion of activated primary human hepatic stellate cells

摘要: Background Liver fibrosis is characterized by the excessive formation and accumulation of matrix proteins as a result wound healing in liver. A main event during fibrogenesis activation liver resident quiescent hepatic stellate cell (qHSC). Recent studies suggest that reversion activated HSC (aHSC) phenotype into quiescent-like could be major cellular mechanism underlying regression liver, thereby offering new therapeutic perspectives for treatment fibrosis. Whether human HSCs have ability to undergo similar currently unknown. The aim present study identify experimental conditions can revert vitro primary consequently map molecular events associated with this process gene expression profiling.