Cd37-binding molecules and immunoconjugates thereof
作者： Lingyun Rui , Peter Park , Daniel Tavares , Jutta Deckert
DOI:
关键词:
摘要: Novel anti-cancer agents, including, but not limited to, antibodies and immunoconjugates, that bind to CD37 are provided. Methods of using the antibodies, or such as methods inhibiting tumor growth further
glgoo.top参考文章(289)
Luis Paz-Ares, Denis Soulières, Ivan Melezínek, Joachim Moecks, Lorenz Keil, Tony Mok, Rafael Rosell, Barbara Klughammer, Clinical outcomes in non-small-cell lung cancer patients with EGFR mutations: pooled analysis Journal of Cellular and Molecular Medicine. ,vol. 14, pp. 51- 69 ,(2010) , 10.1111/J.1582-4934.2009.00991.X
Diane E. Milenic, Karen J. Wong, Kwamena E. Baidoo, Geoffrey L. Ray, Kayhan Garmestani, Mark Williams, Martin W. Brechbiel, Cetuximab: preclinical evaluation of a monoclonal antibody targeting EGFR for radioimmunodiagnostic and radioimmunotherapeutic applications. Cancer Biotherapy and Radiopharmaceuticals. ,vol. 23, pp. 619- 631 ,(2008) , 10.1089/CBR.2008.0493
Hideharu Kimura, Kazuko Sakai, Tokuzo Arao, Tatsu Shimoyama, Tomohide Tamura, Kazuto Nishio, Antibody-dependent cellular cytotoxicity of cetuximab against tumor cells with wild-type or mutant epidermal growth factor receptor Cancer Science. ,vol. 98, pp. 1275- 1280 ,(2007) , 10.1111/J.1349-7006.2007.00510.X
Felicity C. Kalinowski, Keith M. Giles, Patrick A. Candy, Alishum Ali, Clarissa Ganda, Michael R. Epis, Rebecca J. Webster, Peter J. Leedman, Regulation of Epidermal Growth Factor Receptor Signaling and Erlotinib Sensitivity in Head and Neck Cancer Cells by miR-7 PLoS ONE. ,vol. 7, pp. e47067- 16 ,(2012) , 10.1371/JOURNAL.PONE.0047067
Katharine C. Lai, Hans K. Erickson, Xiuxia Sun, Peter U. Park, Jutta Deckert, Min Li, Yong Yi, Jan Pinkas, Jennifer A. Coccia, Sara Nadworny, Abstract B209: The CD37-targeting ADC IMGN529 combines the potent anticancer activity of K7153A antibody with efficient maytansinoid delivery. Molecular Cancer Therapeutics. ,vol. 10, ,(2011) , 10.1158/1535-7163.TARG-11-B209
Helmout Modjtahedi, Toshi Komurasaki, Hitoshi Toyoda, Christopher Dean, Anti-EGFR monoclonal antibodies which act as EGF, TGFα, HB-EGF and BTC antagonists block the binding of epiregulin to EGFR-expressing tumours International Journal of Cancer. ,vol. 75, pp. 310- 316 ,(1998) , 10.1002/(SICI)1097-0215(19980119)75:2<310::AID-IJC22>3.0.CO;2-F
Iwao Ojima, Guided Molecular Missiles for Tumor-Targeting Chemotherapy—Case Studies Using the Second-Generation Taxoids as Warheads Accounts of Chemical Research. ,vol. 41, pp. 108- 119 ,(2008) , 10.1021/AR700093F
Urpo Lamminmäki, Jussi A. Kankare, Crystal Structure of a Recombinant Anti-estradiol Fab Fragment in Complex with 17β-Estradiol Journal of Biological Chemistry. ,vol. 276, pp. 36687- 36694 ,(2001) , 10.1074/JBC.M102367200
Iwao Ojima, Xudong Geng, Xinyuan Wu, Chuanxing Qu, Christopher P. Borella, Hongsheng Xie, Sharon D. Wilhelm, Barbara A. Leece, Laura M. Bartle, Victor S. Goldmacher, Ravi V. J. Chari, Tumor-Specific Novel Taxoid−Monoclonal Antibody Conjugates Journal of Medicinal Chemistry. ,vol. 45, pp. 5620- 5623 ,(2002) , 10.1021/JM025540G
A. Ullrich, L. Coussens, J. S. Hayflick, T. J. Dull, A. Gray, A. W. Tam, J. Lee, Y. Yarden, T. A. Libermann, J. Schlessinger, J. Downward, E. L. V. Mayes, N. Whittle, M. D. Waterfield, P. H. Seeburg, Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells Nature. ,vol. 309, pp. 418- 425 ,(1984) , 10.1038/309418A0