Method of treatment of tumors that are resistant to egfr therapies by egfr antibody cytotoxic agent conjugate
作者： Thomas Chittenden , Julianto Setiady , Peter U. Park
DOI:
关键词:
摘要: The present invention relates to the identification that EGFR antibody immunoconjugates are effective in inhibiting growth of tumor ceils have developed and/or ALK resistance mechanisms. Methods administering patients having resistant toner cells is also disclosed.
google.co.jp 参考文章(156)
Lucilla Steinaa, Klaus Koefoed, Lars Soegaard Nielsen, Per-Johan Meijer, Robert Carlsson, Charles Pyke, Mikkel Wandahl Pedersen, Allan Jensen, Recombinant Anti-Epidermal Growth Factor Receptor Antibody Compositions ,(2008)
Ralph H. Schwall, Sharon Erickson, Mark X. Sliwkowski, Walter A. Blattler, Methods of treatment using anti-erbb antibody-maytansinoid conjugates ,(2000)
Anthony J Mutsaers, Giulio Francia, Shan Man, Christina R Lee, John ML Ebos, Yan Wu, Larry Witte, Scott Berry, Malcolm Moore, Robert S Kerbel, None, Dose-Dependent Increases in Circulating TGF-α and Other EGFR Ligands Act As Pharmacodynamic Markers for Optimal Biological Dosing of Cetuximab and Are Tumor Independent Clinical Cancer Research. ,vol. 15, pp. 2397- 2405 ,(2009) , 10.1158/1078-0432.CCR-08-1627
Monika Jost, Teresa M. Huggett, Csaba Kari, Ulrich Rodeck, Matrix-independent Survival of Human Keratinocytes through an EGF Receptor/MAPK-Kinase-dependent Pathway Molecular Biology of the Cell. ,vol. 12, pp. 1519- 1527 ,(2001) , 10.1091/MBC.12.5.1519
Roberto Bianco, Teresa Troiani, Giampaolo Tortora, Fortunato Ciardiello, Intrinsic and acquired resistance to EGFR inhibitors in human cancer therapy. Endocrine-related Cancer. ,vol. 12, ,(2005) , 10.1677/ERC.1.00999
Aya Jakobovits, Michael Gallo, Xiao-Dong Yang, Xiao-Chi Jia, Human monoclonal antibodies to epidermal growth factor receptor ,(1998)
Detlef Gussow, Elisabet Rosell, Francesc Mitjans, Mary M. Bendig, Francesc Blasco, Jaime Piulats, Jaime Adan, Catherine A. Kettleborough, Keith H. Ansell, Anti-EGFR single-chain Fvs and anti-EGFR antibodies ,(1995)
Con Panousis, Terrance Grant Johns, Antony Wilks Burgess, Andrew Mark Scott, Huei-Jen Su Huang, V. Peter Collins, Christoph Renner, Lloyd J. Old, Webster K. Cavenee, Elisabeth Stockert, Edouard Collins Nice, Achim Jungbluth, Gred Ritter, Specific binding proteins and uses thereof ,(2002)
Jussi P. Koivunen, Craig Mermel, Kreshnik Zejnullahu, Carly Murphy, Eugene Lifshits, Alison J. Holmes, Hwan Geun Choi, Jhingook Kim, Derek Chiang, Roman Thomas, Jinseon Lee, William G. Richards, David J. Sugarbaker, Christopher Ducko, Neal Lindeman, J. Paul Marcoux, Jeffrey A. Engelman, Nathanael S. Gray, Charles Lee, Matthew Meyerson, Pasi A. Jänne, EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer Clinical Cancer Research. ,vol. 14, pp. 4275- 4283 ,(2008) , 10.1158/1078-0432.CCR-08-0168
José Baselga, Why the Epidermal Growth Factor Receptor? The Rationale for Cancer Therapy Oncologist. ,vol. 7, pp. 2- 8 ,(2002) , 10.1634/THEONCOLOGIST.7-SUPPL_4-2