EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer

作者: Jussi P. Koivunen , Craig Mermel , Kreshnik Zejnullahu , Carly Murphy , Eugene Lifshits

DOI: 10.1158/1078-0432.CCR-08-0168

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摘要: … Identification of EML4-ALK fusion genes in NSCLC cell lines. To rapidly screen our panel of 83 lung cancer cell lines (Supplementary Table S1) for potential ALK translocations, we …

参考文章(30)
John D. Minna, Adi Gazdar, Joyce E. Ohm, Denise Juroske, Jonathan R. Pollack, Michael Peyton, Kiyoshi Yanagisawa, Yuhui Huang, Joseph Amann, J. Stuart Salmon, Hisayuki Shigematsu, David P. Carbone, Pierre P. Massion, Shailaja Kalyankrishna, Young H. Kim, Jonathan M. Kurie, Luc Girard, Aberrant epidermal growth factor receptor signaling and enhanced sensitivity to EGFR inhibitors in lung cancer Cancer Research. ,vol. 65, pp. 226- 235 ,(2005)
A. Jemal, R. Siegel, E. Ward, T. Murray, J. Xu, M. J. Thun, Cancer statistics, 2007. CA: A Cancer Journal for Clinicians. ,vol. 57, pp. 43- 66 ,(2007) , 10.3322/CANJCLIN.57.1.43
J. M. Stommel, A. C. Kimmelman, H. Ying, R. Nabioullin, A. H. Ponugoti, R. Wiedemeyer, A. H. Stegh, J. E. Bradner, K. L. Ligon, C. Brennan, L. Chin, R. A. DePinho, Coactivation of Receptor Tyrosine Kinases Affects the Response of Tumor Cells to Targeted Therapies Science. ,vol. 318, pp. 287- 290 ,(2007) , 10.1126/SCIENCE.1142946
Ming-Sound Tsao, Akira Sakurada, Jean-Claude Cutz, Chang-Qi Zhu, Suzanne Kamel-Reid, Jeremy Squire, Ian Lorimer, Tong Zhang, Ni Liu, Manijeh Daneshmand, Paula Marrano, Gilda da Cunha Santos, Alain Lagarde, Frank Richardson, Lesley Seymour, Marlo Whitehead, Keyue Ding, Joseph Pater, Frances A. Shepherd, Erlotinib in lung cancer - molecular and clinical predictors of outcome. The New England Journal of Medicine. ,vol. 353, pp. 133- 144 ,(2005) , 10.1056/NEJMOA050736
Yupo Ma, Quan Lin, Yasushi Fujio, Keita Kunisada, Vasiliki Leventaki, Pamela Das, George Z Rassidakis, Cathy Cutler, L Jeffrey Medeiros, Raymond Lai, Hesham M Amin, Timothy J McDonnell, Selective inhibition of STAT3 induces apoptosis and G1 cell cycle arrest in ALK-positive anaplastic large cell lymphoma Oncogene. ,vol. 23, pp. 5426- 5434 ,(2004) , 10.1038/SJ.ONC.1207703
K. Pulford, S.W. Morris, F. Turturro, Anaplastic lymphoma kinase proteins in growth control and cancer. Journal of Cellular Physiology. ,vol. 199, pp. 330- 358 ,(2004) , 10.1002/JCP.10472
Roberto Chiarle, William J Simmons, Honjying Cai, Girish Dhall, Alberto Zamo, Regina Raz, James G Karras, David E Levy, Giorgio Inghirami, Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic target Nature Medicine. ,vol. 11, pp. 623- 629 ,(2005) , 10.1038/NM1249
Toru Mukohara, Gabriel Civiello, Bruce E. Johnson, Pasi A. Jänne, Therapeutic targeting of multiple signaling pathways in malignant pleural mesothelioma. Oncology. ,vol. 68, pp. 500- 510 ,(2005) , 10.1159/000086994
A. V. Galkin, J. S. Melnick, S. Kim, T. L. Hood, N. Li, L. Li, G. Xia, R. Steensma, G. Chopiuk, J. Jiang, Y. Wan, P. Ding, Y. Liu, F. Sun, P. G. Schultz, N. S. Gray, M. Warmuth, Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK Proceedings of the National Academy of Sciences of the United States of America. ,vol. 104, pp. 270- 275 ,(2007) , 10.1073/PNAS.0609412103