Microsatellite Instability Is Rare in B-Cell Non-Hodgkin's Lymphomas
作者： Riccardo Dalla-Favera , Silvio Roncella , R.S.K. Chaganti , Gianluca Gaidano , Diane C. Louie
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摘要: Microsatellite instability (MSI), a symptom of defect in DNA mismatch repair function, represents type genomic frequently detected many types cancers. However, the involvement MSI non-Hodgkin's lymphomas (NHL) has not been conclusively investigated. In this study, we have tested presence 69 cases B-cell NHL (B-NHL) representative various histologic categories disease and including 17 acquired immunodeficiency syndrome (AIDS)-related B-NHL (AIDS-NHL). addition, for selected cases, consecutive samples obtained before after clinical progression (with without concomitant transformation) were also Five distinct microsatellite repeats (2 dinucleotide, 2 trinucleotide, 1 tetranucleotide repeats) analyzed by polymerase chain reaction all cases. MSI, defined alterations two or more five loci tested, was found NHL. contrast to previous study reporting frequent association between AIDS-NHL, abnormality only AIDS-NHL major subtypes. Overall, these data indicate that defects do contribute significantly molecular pathogenesis B-NHL.
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