Tetrahydrobiopterin in Cardiovascular Health and Disease

摘要: Tetrahydrobiopterin (BH4) functions as a cofactor for several important enzyme systems, and considerable evidence implicates BH4 key regulator of endothelial nitric oxide synthase (eNOS) in the setting cardiovascular health disease. bioavailability is determined by balance enzymatic de novo synthesis recycling, versus degradation oxidative stress. Augmenting vascular levels pharmacological supplementation has been shown experimental studies to enhance NO bioavailability. However, it become more apparent that role other pathways, including NOS isoforms aromatic amino acid hydroxylases, may have bearing on aspects homeostasis, inflammation, cardiac function. This article reviews development well pathophysiological processes such dysfunction, atherosclerosis, hypertrophy. We discuss therapeutic potential disease states attempt address how this modulator intracellular NO-redox ultimately provide powerful new treatment many diseases.