Perfusion MDCT of prostate cancer: Correlation of perfusion CT parameters and immunohistochemical markers of angiogenesis

摘要: OBJECTIVE. The aim of our study was to correlate perfusion MDCT parameters and immunohistochemical markers angiogenesis in prostate cancer. SUBJECTS AND METHODS. Twenty-two patients scheduled for radical surgical prostatectomy because biopsy-proven cancer underwent CT on a 64-MDCT scanner. Eight contiguous 5-mm sections were acquired at 1-second intervals 45 seconds followed by three additional scans every 10 after the administration 80 mL iodinated contrast medium (350 mg I/mL). Blood volume, blood flow, mean transit time, permeability surface-area product calculated, dividing each slice into nine square regions. Values obtained correlated with microvessel density (MVD) vascular area corresponding areas histologic macrosections. RESULTS. values detected all fields cancer, benign hyperplasia, chronic prostatitis, healthy tissue were, respectively, 18...