Testicular toxicity and reduced sertoli cell numbers in neonatal rats by di(2-ethylhexyl) phthalate and the recovery of fertility as adults

摘要: Neonatal and adult rats (1, 2, 3, 6, 12 weeks of age) were given five daily oral doses di(2-ethylhexyl) phthalate (DEHP) (0, 10, 100, 1000, 2000 mg/kg) histological changes in the testes examined 24 hr after last dose. Relative testis weights reduced at 1000 mg/kg 1, 6-week-old but not 12-week-old rats, while fatal to suckling caused decreased relative weight death 6- rats. In neonatal (1 week old), DEHP (1000 a 35% decrease Sertoli cell numbers 2- 3-week-old showed losses spermatocytes cells. The loss both spermatids and/or mg/kg. Total testicular zinc concentrations (3-week) or weaned (6-week) results support hypothesis that is primary target ester toxicity since effects observed an age when only cells present. Fertility was assessed mating trials male exposure on Days 6–10. Although number dose, normal 6 13 age. However, there dose-related maturation tubules. There no consistent fertility, implantation rate, live fetuses untreated females mated with DEHP-treated males. decreases spermatid 19 11, 12, 16, 23 Therefore, due neonatally did affect fertility as adults, may have subtle sperm production.