High nitrogen stainless steel drug-eluting stent - Assessment of pharmacokinetics and preclinical safety in vivo.

摘要: Pharmacokinetic analyses were performed using 20 pigs for 120-days implantation, while one sirolimus-eluting stent was implanted into of their coronary artery. At different time points, the residual sirolimus on stent, delivered locally (to artery wall), regionally adjacent and downstream muscle) systemically plasma visceral organs), detected throughout 120 days. Preclinical safety evaluation 32 180-days implantation to study metal platform material effectiveness eluting coating HNS stent. The neointima area, restenosis rate inflammatory grade control group stents analyzed. Approximately 80% eluted from after 30-days in vivo. Additionally, there sustained wall, cardiac muscle heart accumulated peak at 90-days implantation. It inferred that this covered by before indicating safe effective. Very little distributed organs 14-days exhibited lower than group, which verified design reasonable practical. In addition, no significant difference score between bare-metal drug-eluting stents, illustrating has good bio-compatibility is suitable use as material.