Clinical use of sirolimus-eluting stents.

摘要: Drug-eluting stents, or intracoronary stents that combine the local delivery of antirestenotic pharmacologic therapies while maintaining mechanical advantage bare metal over balloon angioplasty alone, are a highly complex technology have profoundly affected practice percutaneous coronary intervention last 5 years. These devices were designed specifically to treat neointimal hyperplasia occurring after conventional stent placement, and been remarkably successful in this regard. However, recent concerns raised regarding long-term safety these devices, particularly when used outside specific patient lesion subsets studied pivotal randomized trials led device approval by regulatory bodies within United States abroad. This review aims present brief description sirolimus-eluting platform its mechanism action, followed an overview current data efficacy clinical use technology.