Pharmacological modulation of voltage-gated potassium channels as a therapeutic strategy
作者： Neil A Castle
DOI: 10.1517/13543776.2010.513384
关键词:
摘要: Importance of the field: The human genome encodes at least 40 distinct voltage-gated potassium channel subtypes, which vary in regional expression, pharmacological and biophysical properties. Voltage-dependent (Kv) channels help orchestrate many physiological pathophysiological processes that promote sometimes hinder healthy functioning our bodies.Areas covered this review: This review summarizes patent scientific literature reports from past decade highlighting opportunities Kv offer for development new therapeutic interventions a wide variety disorders.What reader will gain: gain an insight analysis associations different family members with disease processes, summary evaluation therapeutically relevant modulators these channels, particularly focusing on proprietary agents being developed.Take home message: Development drugs target K...
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