An Ultrasensitive Non-Enzymatic Sensor for Quantitation of Anti-Cancer Substance Chicoric Acid Based on Bimetallic Nanoalloy with Polyetherimide-Capped Reduced Graphene Oxide.

摘要: Exploiting effective therapies to fight tumor growth is an important part of modern cancer research. The anti-cancer activities many plant-derived substances are well known, in because the often extensively distributed. Chicoric acid, a phenolic compound widely distributed plants, has drawn widespread attention recent years its extraordinary activities. However, traditional methods for quantifying chicoric acid inefficient and time-consuming. In this study, ultrasensitive non-enzymatic sensor determination was developed based on use Au@Pt-polyetherimide-reduced graphene oxide (PEI-RGO) nanohybrid-modified glassy carbon electrode. Owing considerable conductivity PEI-functionalized RGO efficient electrocatalytic activity Au@Pt nanoalloys, designed exhibited high capacity measurement, with low detection limit 4.8 nM (signal-to-noise ratio 3) broad linear range four orders magnitude. With advantages provided by synergistic effects nanocomposites PEI-RGO, also revealed exceptional electrochemical characteristics, including superior sensitivity, fast response, acceptable long-term stability, favorable selectivity. This work provides powerful new platform highly accurate measurement quantities, facilitating further research into potential as treatment.